Depression is often said to be caused by a chemical imbalance in the brain, and this is what most drug treatments are based on.

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Depression is often said to be caused by a chemical imbalance in the brain, and this is what most drug treatments are based on. Certainly in many cases, there is a reduction in the amount of certain neurotransmitters found (monoamines such as serotonin and norepinephrine) in depressed people. Depression, or major depressive disorder, is a mental health condition marked by an extended sense of sadness and despair that affects how a person thinks, feels and functions. The condition may significantly interfere with a person's daily life and may prompt thoughts of suicide.

Depression isn't the same as sadness and grief caused by a challenging life experience, such as the death of a loved one. An imbalance in the brain's signaling chemicals may be responsible for the condition in many of the patients. However, there are several theories about what this imbalance actually is and which signaling chemicals are involved. Moreover, a variety of distressing life situations are also associated, including early childhood trauma, a job loss, the death of a loved one, financial troubles, or a divorce.

Most likely, depression is caused by a combination of genetic, biological, environmental, and psychological factors. Certain medical conditions may also trigger depression, including an under active thyroid gland, cancer, prolonged pain and other significant illnesses. Hormonally induced depression can arise after childbirth or at menopause as well. Additionally, sedatives and high blood pressure medications are linked to depression,

People with depression may experience a variety of symptoms, but most commonly, "a deep feeling of sadness or a marked loss of interest or pleasure in activities". Other symptoms of depression may include:

Irritability, agitation or restlessness
Lower sex drive
Inability to focus
Insomnia or excessive sleeping
Change is appetite, eating too much or too little
Chronic fatigue and lethargy
Unexplainable crying spells
Unexplainable physical symptoms such as headaches or body aches
Feeling hopeless and worthless
Withdrawal from social situations and normal activities
Thoughts of death or suicide.

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